They've spent big on three signings - Romelu Lukaku, Nemanja Matic and Victor Lindelof - while West Ham themselves have also strengthened.
Joe Hart has come in on loan, while Pablo Zabaleta, Marko Arnautovic and former United striker Javier Hernandez have also arrived at the London Stadium.
Slaven Bilic's side finished 11th last season, 17 points worse off than the previous campaign.
Team News
Luke Shaw, Ashley Young and Marcos Rojo remain out as they continue to recover from long-term injuries sustained last season.
Eric Bailly and Phil Jones missed Tuesday's UEFA Super Cup defeat to Real Madrid through suspension, but their continental suspension does not impact domestic matches.
West Ham expect defender Aaron Cresswell to be available for their opening Premier League match on Sunday.
Captain Mark Noble has shaken off a minor toe problem which saw the midfielder miss a couple of day's training, but Michail Antonio will not be involved as he continues his recovery from a hamstring injury with a run-out for the Under 23s against Everton on Friday night.
POSSIBLE STARTING LINE-UPS
Man. Utd (4-3-3): De Gea; Valencia, Smalling, Lindelof, Blind; Pogba, Mata, Matic; Rashford, Mkhitaryan, Lukaku
West Ham (4-2-3-1): Hart; Zabaleta, Reid, Ogbonna, Cresswell; Obiang, Kouyate; Antonio, Lanzini, Arnautovic; Chicharito
Kick-off: Sunday 13th August 2017, 4:00 pm
Venue(Stadium): Old Trafford
Last encounter: Man. Utd 1 West Ham 1
Our Prediction: Man. Utd 2 West Ham 1
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